The article underwent a pre-acceptance process lasting 3 months. It is well known that iScience has high requirements for journal formatting. Therefore, modifications were made according to the STAR Methods format during the first major revision, and supplementary materials were submitted. The journal requires that code must be open source. iScience is no longer under Elsevier and is now part of Cell Press, with certain requirements for paper innovation. I just want to say that iScience is also science, haha. Best wishes to all colleagues for a smooth acceptance of their articles!

2026.6.20 submitted manuscript
2026.6.21 with editor
2026.7.16 all reviewers complete
2026.7.30 major revision
2026.8.18 Revision Submitted to Journal
2026.9.1 minor revision
2026.9.1 Revision Submitted to Journal
2026.9.14 pre-accept
2026.9.14 Revision Submitted to Journal

(2) 讚！ | XIEDONG

The article was finally accepted after more than 5 months. It is worth noting that when the article was first submitted, there were no specific requirements for the format. However, once it reached the Pre-Accept stage, the journal had strict formatting requirements. It took 3 revisions to meet the requirements, so everyone should carefully review the journal's formatting requirements to avoid wasting time.

2026.3.14 Submitted manuscript
2026.5.5 Major revision
2026.6.20 Revision submitted to journal
2026.6.22 With editor
2026.6.23 Under review
2026.7.29 Pre-Accept
2026.8.7 Revision submitted to journal
2026.8.13 Pre-acceptance
2026.8.19 Revision submitted to journal
2026.8.24 Accept

(1) 讚！ | 123

After the major revision, there were three reviewers - one accepted, one recommended minor revisions, and one rejected. However, the editor ultimately rejected it, which is totally unreasonable. It took four months to complete the major revision, including adding animal models. It's really a waste of time!!!

(0) 讚！ | DarS

May 12 STJ With editor
May 25 ARC
Jun 9 Pre-accapt

(0) 讚！ | ChongSCI

Isn't this the second major repair? There's no such thing as a second minor repair.

(0) 讚！ | 阿Jie

I'm sorry, but I need the text you would like me to translate.

(0) 讚！ | 阿Jie

From September 25th of year 25 to August of year 26, a total of one major revision, two minor revisions, and three rounds of rejection with over ten questions raised were experienced. During this period, two changes of reviewers occurred, totaling five different reviewers. It seemed like everyone agreed on the third review, but the editor disagreed, suspecting the use of AI to raise over ten questions, and then rejected it. The specific timeline is as follows:
- September 19, 2025: Submitted manuscript
- October 9, 2025: With editor, requested additional materials and format modifications before review
- October 17, 2025: Revision submitted to journal, additional materials submitted
- November 17, 2025: Under review
- December 7, 2025: Major revision requested, feedback received
- February 5, 2026: Revision submitted to journal
- February 6, 2026: With editor
- March 16, 2026: Under review
- June 15, 2026: Major revision requested, feedback received
- July 9, 2026: Revision submitted to journal
- August 2026: Reject
It has taken too much time, and those in a hurry are not advised to submit.

(0) 讚！ | yangguangchat

Brother, how long has it been since your first round of ARC? It's been 10 days for me and still no news.

(0) 讚！ | XIEDONG

I am a medical AI plus clinical. The speed of review is acceptable, and the innovation requirements are not high. The workload is almost enough to be accepted. I feel that one of the reviewers is an AI. They asked me to add 7 sensitivity analyses and various statistical tests. It feels like the AI is suggesting it at a glance. I had to add them anyway. Fortunately, I was finally accepted.

(0) 讚！ | hehiedsafsawde

How are you, friend? How long did your first round of ARC last?

(0) 讚！ | XIEDONG

Share some time dynamics
6.20 summit
6. Twenty-five, six, UR
7.16 APC
By the way, how long does APC take? Why has it been two days and the editor still hasn't made a decision, what does this mean? I see many other research friends also waiting for several days.

(0) 讚！ | XIEDONG

Most of the journals from Cell Press cannot be tracked using the Elsevier tracking system.

(0) 讚！ | 6个6

Do comrades know how to check specific dynamics? Isn't isciene under the umbrella of Elsevier? Why can't I find it on the WeChat mini program, even though the communication name is filled in correctly, with the last name and first name? Besides uuid, are there any other ways to check?

(0) 讚！ | XIEDONG

Hello, have you heard any news?

(0) 讚！ | kyxb

There were no new reviewers, and it has always been an issue with the three reviewers. The first response did not completely resolve the issue, and the reviewers were not satisfied. However, by the time of the third review, all reviewers were in agreement. Subsequent revisions were only for formatting.

(0) 讚！ | 实验室工具

6.17 finalize requirements
6.17 revised
6.18 with editor
6.20 accept

(0) 讚！ | 实验室工具

Hello, are there any new reviewers added for the intermediate review and final review?

(0) 讚！ | kyxb

I replied to the reminder email by the end of May, and now the paper has been published online, but I have not yet received an email from the APC.

(0) 讚！ | 纯棉

6.17 完善，生产需求
6.17 修订
6.18 与编辑进行最后确认

(0) 讚！ | 实验室工具

Why are there so many rounds of revision after pre-acceptance? Are the editing requirements very strict?

(0) 讚！ | 实验室工具

2025.12.22 submit
2026.1.13 under review
2026.2.17 major revision
2026.3.12 revised
2026.3.18 under review
2026.4.20 major revision
2026.5.3 revised
2026.5.15 under review
2026.6.4 accept in principle
2026.6.6 revised
2026.6.9 under review
The current status is unknown.

(0) 讚！ | 实验室工具

How long does it usually take to receive the APC? Just curious.

(0) 讚！ | _darktempler

On our end, we have also officially received it, it's been almost half a month, but we haven't received the APC and proof emails yet. How long does it usually take?

(0) 讚！ | _darktempler

Has your manuscript been proofread now?

(0) 讚！ | asdfghjklzxcvbnm

It has been over seven months since the submission, and it is still under review. It's too slow.

(0) 讚！ | 小人